Hello.
My name is Robert, and I am the founder of SUPADERMA.
I am a biologist and environmental scientist, and I study the medical literature through the internet.
A year ago I was looking for a way to cure a genetic disorder called X-Linked Adrenoleukodystrophy. To cut a long story short, this disease is caused by a mutation in the gene (called ABCD1) needed to remove very long chain fatty acids (VLCFA) from the body. Without this gene, the VLCFA accumulate and the end result is that the myelin sheath deteriorates and atrophies.
There is another gene (called ABCD2) that can do the same thing, but this one is pretty much always switched off, and it has proven all but impossible to get it switched on.
This second gene can be switched on by a nuclear receptor called PPARa. This receptor pairs up with another called RXR to create a sandwich (heterodimer). When a little flag (ligand) attaches itself to this heterodimer, the whole complex becomes activated and can move into the nucleus and switch on the ABCD2 gene, by sitting on the gene's promoter region.
I had been searching for a suitable ligand that would switch on the ABCD2 gene, and finally found that phytanic acid is a very strong ligand for the PPARa/RXR heterodimer.
So I set out to make some purified phytanic acid, and I did this by boiling spinach in a special way with water and oil so that it released PHYTOL (a form of phytanic acid) from the chlorophyll in the spinach.
I was filtering the extract, but it was taking too long. So I dumped the boiled spinach into a muslin bag, and squeezed hard, to get the oil out of the extract.
Little did I know then that phytanic acid is a mutagen and an allergen, and I squeeezed the bag with my bare hands (left over right). Within hours, I felt pricking sensations, and the next day my right hand was covered in minute subcutaneous blisters, which soon merged together to form cracks and welts all over my hand, leaving painful cuts.
This disorder is called dyshidrosis, a very robust form of atopic dermatitis. The cracks in the skin would not heal, and gradually got worse. The skin's outer layers (stratum corneum and stratum granulosum) had lost their ability to organise their intracellular spaces into an impenetrable multilamellar matrix, resulting in a seriously impaired permeability barrier. Water containing bacteria was now easily able to enter the stratum corneum's interstitial spaces, calling up the inflammatory immune response (redness, itchy, blistering, skin warm to the touch). When dry, the skin dried right out, and became brittle and fragile, increasing the cuts and sores. In some places skin would drop off in flakes (desquamification), and other parts would just thicken into a cornified layer. At one point the whole of my palm sloughed off in pieces, leaving red raw areas. There seemed no end to it.
My G.P. prescribed various creams and antibacterials, as well as hydrocortisone creams. He said that dermatitis never completely goes away, and flare-ups would continue for the rest of my life.
Being a biologist with a strong bent for medicine, I determined that if the doctors couldn't cure me, I would cure myself. Thus began a long and arduous research and experimentation scenario, with my hand as the guinea pig. I read everything I could find from the internet: articles, research papers, symposiums, and microbiology papers.
I tried a million different possibilities, went down many wrong paths, and finally came to realise that the skin itself was not the problem, it was the fact that the skin was unable to organise itself properly, due to a lack of the right resources. In my case the problem was a deficiency of available nutrients, caused by the initial insurgence of phytanic acid. This had acted as a permanent ligand for the PPARa/RXR heterodimers in all of my hand's skin cells, such that each cell had its ABCD2 gene switched on as well as its ABCD1 gene, resulting in a double whammy of VLCFA removal, the exact opposite of what happens with X-Linked Adrenoleukodystrophy.
9-cis retinoic acid is the only known natural ligand for RXR. I figured maybe this molecule (available on prescription as alitretinoin, brand name TOCTINO) could be used as an alternative ligand for the PPARa/RXR heterodimer, and maybe this liganded complex would not be permanent, and maybe it could be used to swap out the permanent phytanic acid ligands, thus deactivating the ABCD2 gene. This therapy did work to some extent, but it did not cure the problem. I still needed the plasters and the emollients, my skin was still covered in cuts, the permeability barrier remaining impaired.
I then formulated SUPADERMA SKIN REPAIR CREAM, using all natural products. This repair cream contains all the nutrients that were lacking in my hand's skin cells. As soon as I started using this formulation, I noticed immediate improvement. Within days the inflammation had gone, the cuts were able to mesh together under the plasters (which I used to pull the two sides together).
I had a deep cut on the end of my little finger, which had refused to heal for months. Within two weeks this cut had subsided, drawn together, and was healing rapidly. Within a month, all of the cuts had disappeared completely. The nutrients in SUPADERMA SKIN REPAIR CREAM had enabled the skin cells to reorganise their intracellular spaces with the right mixture to form a close-knit matrix, so that water was now prevented from entering or leaving the skin tissue, thus restoring the skin's permeability barrier.
As time went on I continued to re-invent better versions of this cream. Now, only a few months later, the skin of my right hand is identical to that of the left hand, with no cuts or abrasions, no blistering, and not even one tell-tale scar !!! Thanks to SUPADERMA SKIN REPAIR CREAM's breakthrough formula, my hand is now as good as new.
If you want to view the "Before and after" photos, please visit the SUPADERMA website at:
http:/www.supaderma.com
Right now I am offering a FREE TRIAL of SUPADERMA SKIN REPAIR CREAM at absolutely no charge or obligation of any kind, and it's postage-free to addresses in the U.K. Just open up the website, and email me at:
supaderma@talktalk.net
The only thing I ask is if you do get some for free, please let me know whether it has cured your skin disorder (whether it be dermatitis, psoriasis, or eczema). It is only through feedback that I can assess the potential of this breakthrough discovery, and which disorders it can help or cure.
Cheers, Rob.
